Contractile responsiveness to agonists of reconstituted smooth muscle fiber from cultured smooth muscle cells.
نویسندگان
چکیده
منابع مشابه
Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists.
The important pathophysiological features of the airways in asthma include exaggerated narrowing to bronchoconstrictor agonists and attenuated relaxation to beta adrenoceptor stimulation. These physiological perturbations are associated with inflammation and remodelling of the airways, the latter including an increase in airway smooth muscle cell mass, disruption of the airway epithelium, and c...
متن کاملContractile smooth muscle cells derived from hair-follicle stem cells.
AIMS We hypothesized that hair-follicle stem cells can differentiate toward smooth contractile muscle cells, providing an autologous cell source for cardiovascular tissue regeneration. METHODS AND RESULTS Smooth muscle progenitor cells (SMPCs) were obtained from ovine hair follicles using a tissue-specific promoter and fluorescence-activated cell sorting. Hair-follicle smooth muscle progenito...
متن کاملLong-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells
BACKGROUND Chronic airway diseases, like asthma or COPD, are characterized by excessive acetylcholine release and airway remodeling. The aim of this study was to investigate the long-term effect of muscarinic agonists on the phenotype and proliferation of rabbit tracheal airway smooth muscle cells (ASMCs). METHODS ASMCs were serum starved before treatment with muscarinic agonists. Cell phenot...
متن کاملSynthesis in Cultured Smooth Muscle Cells*
Recently, we have reported on the isolation of a high molecular weight species of soluble elastin from lathyritic chick which was postulated to represent the primary precursor of elastin (proelastin). In order to establish the existence and precursor function of proelastin, second passage rabbit aortic smooth muscle cells, previously shown to be synthesizing insoluble elastin, were pulsed with ...
متن کاملTanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling
Objective(s): Vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of tanshinone IIA on the proliferation and migration of VSMCs induced by advanced glycation end products (AGEs). Materials and Methods: In this study, we examined the effects of tanshinone IIA by cell proliferation assay and cell mi...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)35112-1